AQA A Level Chemistry复习笔记7.3.6 Manufacture of Aspirin

Manufacture of Aspirin

 

Manufacture of Aspirin

  • Acylation reactions have many uses, such as in the pharmaceutical and textile industries for making drugs, e.g. aspirin, and textiles, e.g. cellulose acetate
  • In the industrial manufacture of aspirin, salicylic acid and ethanoic anhydride are reacted together in an acylation reaction to form aspirin and ethanoic acid

7.3.6-Equation-for-synthesising-aspirin

 

Salicylic acid            Ethanoic anhydride                    Aspirin                               Ethanoic acid

Equation showing the manufacture of aspirin

  • The reaction of acyl chlorides with water or alcohols produces carboxylic acid and esters respectively
    • However it is normally a fast, exothermic process with a rapid production of highly corrosive hydrogen chloride gas

     

  • In general, acid anhydrides are preferred over acyl chlorides in the production of aspirin because they are also cheaper to produce, less reactive and the reactions can be more easily controlled
  • For acid anhydrides, the by-product is the less corrosive carboxylic acid compared to hydrogen chloride for acyl chlorides

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