AQA A Level Biology复习笔记8.2.8 Epigenetics & Disease

Epigenetics & Disease

 

Inheritance of epigenetic modifications

  • Epigenetic imprinting is the DNA methylation of certain genes and it occurs during the formation of oocytes and sperm cells
  • A child, therefore, inherits two sets of DNA, one from the mother and one from the father, each with its own epigenetic imprint
  • Imprinting is reversible, therefore the maternal epigenetic imprints that are inherited by a male will become paternal imprints when his sperm are produced so that he passes on paternally imprinted DNA
  • Prader-Willi syndrome is an example of a condition with epigenetic links
    • The syndrome is caused by the silencing of an allele on chromosome 15
    • The severity of the syndrome depends on whether an individual receives the affected DNA from their mother or their father
    • If the mother is a carrier for the defective chromosome, individuals that inherit the chromosome do not develop the syndrome
    • However, if the defective chromosome is inherited from the father, the individual will develop the syndrome

     

Prader-Willi-Syndrome_2

A family tree showing the inheritance of Prader-Willi Syndrome. An individual is only fully affected by the syndrome if they inherit the faulty chromosome from their father.

 

Epigenetic cancer treatment

  • DNA in human tumour cells have changes in DNA methylation and histone acetylation which causes tumour suppressor genes to be silenced and oncogenes to be activated
    • This leads to deregulation of the cell cycle and the formation of tumours

     

  • Some cancer treatments involve drugs that reverse the epigenetic changes through the removal of acetyl and methyl tags
    • Removal of methyl groups from the DNA of tumour suppressor genes will enable the genes to be expressed
    • The proteins produced can then regulate the cell cycle and stop tumours forming from faulty or cancerous cells
    • Removal of acetyl groups from histone proteins attached to oncogenes causes the DNA to wrap more tightly, silencing these genes
    • Reducing the expression of oncogenes stops cancer as faulty cells are able to die through programmed cell death (apoptosis) rather than continuing to replicate, causing cancer

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