2018英特尔ISEF学科最佳作品摘要:生物化学 | Best of Category Abstract: Biochemistry

获奖作品基本信息

年份 2018
学科 生物化学 Biochemistry
学校 Moravian Academy
国家/州 PA,United States of America

获奖作品名称

The Biochemical Interactions of Cardiac Ion-Blocking Agents and Optical Coherence Tomography in vivo for Cardiovascular Diseases

获奖作品摘要

Optical Coherence Tomography (OCT) is a novel 3D-imaging modality, however there has been limited research utilizing OCT to study physiological impacts of ion-blocking drugs, namely Class I, III, and IV antiarrhythmics. An OCT drosophila model was developed for live non-invasive analysis of cardiovascular disease and pharmaceutical testing. With extensive drug delivery protocol optimization, Ca????, K??, and Na?? channel blockers were dissolved into sugar based food at 0.1% and 0.01% of standard human dosage, Amlodipine Besylate, Dofetilide, and Flecainide Acetate, respectively.
108 samples’ heart rate and area were processed through a Segmentation and Python algorithms at Instar Stage III and adult. Ultimately, Amlodipine suppressed chronotropy while proarrhythmic characteristics were surprisingly observed in Dofetilide and Flecainide treated samples, signaling potential cardiotoxicity.
Combining chemical therapeutics with bio-optics yields novel implications for potential of optogenetics in cardiotherapy for major chronic heart diseases with 3-dimensional live graphics and enhances understanding of the antiarrythmic biochemical agents currently used to treat them.
The drosophila optical model is an effective way to analyze the chronotropic properties of antiarrythmics to easily test the biomechanical effects of drugs before experimenting on mammalian species or human populations. This reduces the cost and time of developing drugs by quickly identifying experimental molecules with cardiotoxic effects, enhancing general physiological understanding of the drugs to begin with.

 


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ISEF 简介

英特尔国际科学与工程大奖赛,简称 “ISEF”,由美国 Society for Science and the Public(科学和公共服务协会)主办,英特尔公司冠名赞助,是全球规模最大、等级最高的中学生的科研科创赛事。ISEF 的竞赛学科包括了所有数学、自然科学、工程的全部领域和部分社会科学。ISEF 素有全球青少年科学竞赛的“世界杯”之美誉,旨在鼓励学生团队协作,开拓创新,长期专一深入地研究自己感兴趣的课题。

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英特尔 ISEF 竞赛详细介绍

英特尔 ISEF 全程指导方案

· 数学 · 物理 · 化学 · 生物 · 计算机 · 工程 ·

学科简介:生物化学 Biochemistry

The study of the chemical basis of processes occurring in living organisms, including the processes by which these substances enter into, or are formed in, the organisms and react with each other and the environment.

Subcategories:

Analytical Biochemistry (ANB): The study of biochemical components found in a cell or other biological sample. The study of the separation, identification, and quantification of chemical components relevant to living organisms.

General Biochemistry (GNR): The study of chemical and physiochemical processes, including interactions and reactions, relevant to living organisms.

Medicinal Biochemistry (MED): The study of biochemical processes within the human body, with special reference to health and disease.

Structural Biochemistry (STR): The study of components, functions, and structures of molecules of cells within living organisms. Projects in this subcategory can address various variables of cells through the theories of Chemistry and the laws of Physics.

Other (OTH)Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.